Profile of Gut Bacteria in Hypertensive Patients Based on Terminal Restriction Fragment Length Polymorphism Analysis

Hypertension is a severe public health problem due to its high prevalence worldwide. About 7.5 million deaths or 12.8% of all annual worldwide occur blood pressure. The hypertensive disease also associated with the intestinal bacteria. To our knowledge, diversity gut bacteria in patients has not been reported yet Indonesia. Thus, aims this study were analyze profile compared non-hypertensive based on metagenomic analysis, Terminal Restriction Fragment Length Polymorphism (T-RFLP). results affiliation analysis entire Fragments (TRF) contained 6 groups from 26 TRFs and respondents. Cutting 16S rRNA gene BslI restriction enzyme successfully detected bacterial groups, namely Clostridium subcluster XIVa, Prevotella, cluster IV, XI, Bacteroides others. In patients, higher relative abundance showed IV XIVa. Prevotella lower than non-hypertensive. enterotype I II was Contrarily that III cluster. It worth noting F/B ratio Our data suggest differs